Pill n005 Metformin was first discovered in the late 1920s, but it wasn't until the 1950s that it was extensively studied and eventually approved for use in France in 1957. It wasn't until 1995 that the FDA approved Metformin for use in the United States. The drug is available in several forms, including immediate-release and extended-release tablets, and is often taken twice a day with meals. The extended-release form is taken once a day with the evening meal. Metformin is generally well-tolerated, but like all medications, it can cause side effects. The most common side effects are gastrointestinal, such as diarrhea, nausea, and vomiting. These side effects usually go away on their own over time, but if they persist or are severe, a healthcare provider should be consulted. In addition to its use in the treatment of type 2 diabetes, Metformin has also been studied for other potential uses. Some studies have suggested that it may have a role in the prevention of type 1 diabetes, cancer, and cardiovascular disease. However, more research is needed before these uses can be recommended. Metformin is also sometimes used off-label for the treatment of polycystic ovary syndrome (PCOS), a hormonal disorder that affects women of reproductive age. By reducing insulin resistance, Metformin can help regulate menstrual cycles and improve fertility in women with PCOS. It is important to note that Metformin should not be taken by people with certain medical conditions, such as kidney or liver disease, or by those who are allergic to the drug. It is also important to follow the dosage instructions carefully, as taking too much Metformin can lead to a serious condition called lactic acidosis. Metformin is generally well-tolerated, but like all medications, it can cause side effects. The most common side effects are gastrointestinal, such as diarrhea, nausea, and vomiting. These side effects usually go away on their own over time, but if they persist or are severe, a healthcare provider should be consulted. In addition to its use in the treatment of type 2 diabetes, Metformin has also been studied for other potential uses. Some studies have suggested that it may have a role in the prevention of type 1 diabetes, cancer, and cardiovascular disease. However, more research is needed before these uses can be recommended.